3-Chloro-1-propanol CAS 627-30-5

Formulae structurales ：

Productum Descriptio ：

Properties and  Usus :

Applicationes Solutivi

Cum unica sua structura moleculari amphiphilica (logP=0.82), 3-chloro-1-propanolum (CAS 627-30-5) praebet solubilitatem latae spectrum pro solventibus polaribus (e.g., DMF, acetone) et systematibus non-polaribus (hydrocarbura aliphatica, hydrocarbura aromatica). In synthesis organica sicut hydrogenatio catalyticus et reactio Grignard, constans dielectrica eius (ε=22.3) efficaciter potest regulare polaritatem media reactionis et incrementum efficientiam reactionis. In praxi industriali, hic solventem constituit 12-15% dosage in diluenti photoresist electronicus, et per distillationem azeotropicam recuperationem plus quam 98% consequi potest (punctum ebullitionis 160 ℃).

Intermedia principalia pro synthesis medicamenti

• praeparatio precursoris clopidogrel: per reactionem substitutionis nucleophilica SN2, atomus chlorini eius cum methylesther acidum 2-chlorophenylglycicum condensatur ad structuram centralem thienopyridinae medicamenti antiplatelet construere, et puritas producti finalis est ≥99.5% (detection HPLC)
• synthesis of L-nelfinavir: as a key building block for the introduction of the hydroxypropyl side chain at the C-3 position in the synthetic pathway of HIV protease inhibitors to achieve high enantioselectivity of the chiral center (ee value >99%)
• functionalized derivatization: reacted with phosgene to form chloroformic acid-3-chloropropyl ester (92% yield), the intermediate was further used in the preparation of slow-release drug carriers

Synthesis of industrial chemicals

• surfactant: anionic surfactant (critical micelle concentration CMC=0.8mmol/L) generated by sulfuric acid esterification reaction, applied to textile printing and dyeing auxiliaries and tertiary oil recovery system
• engineering plastics modification: as a plasticizer precursor, grafted to polyvinyl chloride chain segments through ester exchange reaction, which can increase the elongation at break of the material by 40% (ASTM D638 test)
• chemia functionalis: ut agentis alquilatio in synthesis liquoris ionici, praeparatus 1-butyl-3-methylimidazolii chloridum ([BMIM]Cl) cum conductivitate usque ad 12mS/cm (25°C)

Compositum necessitatim conservandum est in atmosphaera inertis (contentus oxygeni <50ppm), commendatur uti cum apparatu fabricato ex aere 304L non ferroso vel PTFE, et applicatio eius in campo pharmaceutico oportet esse conformis ICH Q3C Guidelines Residual Solvents (limites PDE 7.1mg/die).

Condiciones reconditae: Condite in vase signato in loco frigido, sicco. Ab oxidants abstine.

Stipare: Productum hoc in tympanis 25kg refertum est, et potest etiam nativus secundum exigentias clientium