Ginsenosides:Natural active ingredients from ginseng extract

Structural formula：

Ginsenosides COA:

What is Ginsenosides?

Ginsenosides are the main active ingredients in the ginseng plant (e.g. ginseng, American ginseng and Panax ginseng.) FSCI's ginsenosides are standardized saponin active ingredients extracted from ginseng (i.e., Panax ginseng) roots that are more than five years old and formulated for the high-end nutritional, pharmaceutical and cosmetic industries.

Active properties of ginsenosides:

Ginsenoside Rb1

CAS No.: 41753-43-9

Action Characteristics:

Calming and tranquilizing: Rb1 is one of the most common polysaccharide paired saponins among ginsenosides, which can significantly improve insomnia, anxiety and other neurological dysfunctions.

Cognitive function enhancement: Enhance the function of cerebral cortex and improve learning and memory disorders, especially suitable for memory care products for silver-haired people.

Anti-glucocorticoid damage: alleviate adrenocortical dysfunction due to stress, and assist in regulating the hormone system.

Ginsenoside Rb2

CAS No.: 11021-13-9

Action Characteristics:

Antidiabetic: Rb2 can effectively improve insulin sensitivity and regulate glucose metabolic pathway. Animal experiments show that it can significantly reduce the blood glucose level of hyperglycemia model mice (up to 35%).

Anti-fatty liver and anti-obesity: It can regulate the expression of fatty acid synthase (FAS) and inhibit lipogenesis, which is suitable for the development of products for metabolic syndrome.

Anti-inflammatory and immunomodulation: Reduce the expression of TNF-α and IL-6, alleviate chronic inflammation, especially in the liver and intestinal system.

Ginsenoside Rd

CAS No.: 52705-93-8

Action Properties:

Neuroprotective effect: Rd can inhibit glutamate-induced neuronal apoptosis, and has been widely studied for neurological recovery after stroke and adjuvant treatment of Parkinson's.

Anti-inflammatory and antioxidant: it significantly reduces the pro-inflammatory factors TNF-α and IL-1β, attenuates inflammatory damage, and shows good control over chronic neuroinflammation.

Anti-tumor potential: preliminary research shows that Rd can induce apoptosis of cancer cells by activating the p53 pathway, and has certain potential for adjuvant treatment of tumors.

Ginsenoside Re

CAS No.: 52286-59-6

Action Properties:

Cardiovascular protection: Re has been shown to have significant anti-arrhythmic and myocardial ischemic protective effects, and can reduce the degree of myocardial damage by regulating calcium ion channels.

Strong antioxidant capacity: Re promotes the generation of endogenous antioxidant enzymes (e.g. SOD, CAT), scavenges free radicals, and relieves cellular oxidative stress.

Immunomodulation: Re can enhance macrophage activity, improve the level of humoral immunity and cellular immunity, suitable for immune function conditioning products.

Ginsenoside Rg1

CAS No.: 22427-39-0

Action Characteristics:

Central nervous system stimulant: Rg1 can promote neuron survival, synapse formation, and enhance electroencephalographic activity, widely used in brain health and antidepressant health products.

Anti-fatigue: It can improve body endurance and delay the accumulation of lactic acid. It is often used as a non-stimulating endurance-enhancing ingredient in the field of sports nutrition.

Anti-aging and antioxidant: It can significantly enhance the activity of antioxidant enzymes such as SOD and GSH-Px, and delay cell aging.

Ginsenoside Rh1

CAS No.: 63223-86-9

Action Characteristics:

Whitening and Anti-melanin: Rh1 inhibits tyrosinase activity and reduces melanin synthesis, making it suitable for use in whitening skin care products and spot reduction essences.

Estrogen-like Activity: Rh1 is believed to have phytoestrogenic effects, which can alleviate the symptoms of perimenopausal women and is commonly used in women's care products.

Mild anti-inflammatory: It can down-regulate the activity of NF-κB pathway and alleviate mild to moderate inflammatory state.

Ginsenoside Rh2

CAS No.: 78214-33-2

Action Characteristics:

Strong anticancer activity: Rh2 is the most researched antitumor component among ginsenosides, which can significantly induce apoptosis of tumor cells, especially in lung, liver and breast cancers.

Immune Enhancement: Activate NK cell and T cell function, improve immune response ability in tumor environment.

Anti-metastasis and anti-proliferation: Rh2 can inhibit the expression of MMP-9 and reduce the infiltration and metastasis of cancer cells, and is widely used in anti-cancer formulas and medicinal food products.

What is Ginsenosides used for?

Functional foods and nutritional supplements

Ginsenosides are highly active plant extracts recognized in the international functional food market.

Studies have shown that daily supplementation of 200–400 mg of saponin compounds can increase average memory scores by more than 15% within 28 days.

Rh2 can enhance macrophage activity and inhibit tumor cell proliferation (cell inhibition rate > 30%).

Rb1 improves learning ability and enhances brain-derived neurotrophic factor (BDNF) expression.

Medicinal raw materials and Chinese medicine formula granules

Ginsenosides are widely used in cardiovascular, nervous system and anti-cancer adjuvant drugs, and Re and Rd are often used to treat ischemic brain damage.

Their mechanisms of action include: anti-free radicals, stabilizing cell membranes, and inhibiting the release of neurotoxic substances.

High-end skin care and anti-aging cosmetics

Rb1 and Re can stimulate fibroblast activity in cosmetics and increase collagen synthesis by 22%.

Rh2 has a repair function for UVB-damaged cells and is suitable for eye creams, essences, and anti-aging repair skin care products.

Where to Buy Ginsenosides?

Foconsci Chemical Industry supplies a variety of plant extract chemicals,we can provide:

Various versions with high content of monomer saponins (≥20%, ≥50%, etc.)

Customized proportion of mixed saponins

OEM plant capsules, granules, beverage formulas

Provide COA, MSDS, TDS data packages

Storage Conditions：

It is recommended to store in a low temperature, dry and light-proof environment. The original package can be stored stably for 24 months without opening. It should be sealed immediately after use to prevent moisture absorption and discoloration.

Safety Data：

Ginsenosides has been listed as a dietary supplement or herbal ingredient in many countries (such as the US FDA GRAS list)

This product is non-dangerous and can be exported by air/sea. CITES and phytosanitary certificates can be provided (if necessary)

FAQ:

Q: Can each saponin be purchased separately?

A: Yes. We offer both pure monomer powders and compounded ratios to meet different formulation needs.

Q: Are they suitable for sports nutrition or brain health products?

A: Yes, Rb1 and Rd are widely used in brain health formulations to enhance cognitive performance and reduce anxiety levels.

Q: Are there high-purity versions available for pharmaceutical companies to develop?

A: Yes. We can customize up to ≥98% purity monomeric saponin standards or pilot grade active powders.